Obesity

Chronic Inflammation and Us

There is a lot of scientific information regarding chronic inflammation, and its role in many disease and chronic conditions. Chronic inflammation is diet mediated and is a source of premature aging, obesity, degenerative disease, Parkinson’s disease, Alzheimer’s, autoimmune disease, type II diabetes and metabolic syndrome X., food cravingsfood addictions, out of control appetite, and inability to loss body weight. If you want to prevent weight gain or lose some weight you have to know what to do.  You have to create a healthy lifestyle for yourself, which includes stress management, exercises and anti-inflammatory diet. Diet! So many people hate diets, I do too, but I am not really talking about a diet, but an anti-inflammatory lifestyle. It is not easy to do, you have to break old negative habits and create new positive ones.

In average it takes 7-10 days to make it real.  Go slow, reward yourself.  Do not blame yourself for mistakes, if you fall off the track – go back.

So, how does this chronic inflammation start?  It starts on the cell membrane.  Cell plasma membrane consists of a double layer of lipids-fats.  These fats can be easily oxidized by the free radicals. As a result of this process, membranes will be broken down and a substance called arachidonic acid is produced. Arachidonic acid will be further oxidized to produce pro-inflammatory substances called pro-inflammatory prostaglandins.

This cascade of events, called oxidative stress, leads to increased production of free radicals inside the cells, and production of inflammatory chemicals and messengers.  We all have heard about it, now you know how this happens!
This hidden chronic inflammation is a “missing link” in our obesity epidemic.

Now scientists look differently on white adipose tissue-body fat.  They know that adipose tissue is an endocrine organ and produces hormones as other endocrine organs do, such as the thyroid gland, pancreas and others. 
Body fat secretes specific hormones-adipokines.  They are proteins that act as messengers throughout the body and initiate inflammatory response-low grade chronic inflammation.

When people eat a lot of carbohydrates, it stimulates production of insulin by the specific cells in the pancreas.  If they eat more than they need, excess fat will be stored as the fat tissue.  When it happens very frequently, insulin receptors become less sensitive to insulin and blood sugar levels will be elevated, but cells will starve due to lack of sugar.   They need sugar for energy production, for all biochemical reactions that run in the cells, will stimulate more insulin production and eventually, level of sugar in the blood will low-it will bring up hunger and this vicious cycle will continue. This situation with insulin resistance leads to the formation of type II Diabetes –adult onset diabetes, related to overeating of carbs mostly. Elevated level of sugar can lead to metabolic syndrome.   25% of Americans have it; it is manifested as obesity, elevated blood pressure, elevated cholesterol and low HDL (good cholesterol), high triglycerides and DNA damage that lead to premature aging.

What can be done to prevent this pathological cascade of events? We have to change a lot of things in order to feel better, look better and enjoy better life.
We will create anti-inflammatory lifestyle! We can do it!
We will choose anti-inflammatory food, stress management and regular exercise.  I will talk about this more it in my next article.


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